Yanli Wang,
M.D., Ph.D.

The 3D Genome Browser is a web-based genome browser used to visualize the spatial organization of the vertebrate genome. It has several modes to illustrate interactions from cis-regulatory contacts, to topologically-associating domains (TADs), to interchromosomal interactions. Furthermore, the browser integrates tracks from well-known genome browsers such as the WashU Epigenome Browser and UCSC Genome Browser to facilitate the functional annotation of genomic elements. This has allowed research investigators to discover an additional layer of evidence in generating hypotheses regarding the function of non-coding elements and effects of non-coding genetic variants.

Wang et al 2018, Genome Biology (Pubmed)

Received the High Attention Score Honor from Altmetric

In this collaboration with my fellow MD/PhD student at Penn State College of Medicine, we sought to identify the role of circulating microRNAs in the pathogenesis of asthma. Utilizing supervised machine learning, specifically, random forest classification, we were able to identify six circulating microRNAs whose levels were highly predictive of having asthma and therefore could serve as viable biomarkers for the disease.

Panganiban et al 2016, Journal of Allergy and Clinical Immunology (Pubmed)

Mentioned by Penn State News

We performed a variety of next-generation sequencing-based assays (RNA-seq, ATAC-seq, ChIP-seq, whole-genome bisulfite sequencing, and Hi-C) on several adult and embryonic zebrafish (Danio rerio) tissues in an effort to functionally annotate its genome via transcriptomes, map of cis-regulatory elements, heterochromatin, methylome, 3D genomic structure and evolutionary analyses.

Yang et al 2020, Nature (Pubmed)